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KMID : 0043320150380050834
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Archives of Pharmacal Research
2015 Volume.38 No. 5 p.834 ~ p.838
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Characterization of the physicochemical properties of KRK-701P
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Bang In-Jeong
Kim Bong-Jin
Sohn Young-Taek
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Abstract
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KRK-701P is a broad-spectrum antibiotic with methicillin-resistant antibacterial activity. The objective of this preformulation study was to determine the physicochemical properties of KRK-701P. The n-octanol-to-water partition coefficients of KRK-701P were 0.448 at pH 4 and 2.546 at pH 8. One crystal form and one amorphous form of KRK-701P were isolated by recrystallization and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis. After storage for 1 month at 0 % RH (silica gel, 20 °C), 52 % RH (saturated solution of Na2Cr2O7.2H2O/20 °C) and 95 % RH (saturated solution of Na2HPO4/20 °C), the two forms were not transformed.
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KEYWORD
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KRK-701P, Crystal form, DSC, Partition coefficient, PXRD
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